Any feedback?
Literature summary for 2.7.8.17 extracted from
- Identification of the minimal lysosomal enzyme recognition domain in cathepsin D (2005), J. Biol. Chem., 280, 33318-33323.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose | Homo sapiens | initial enzyme in biosynthesis of mannose 6-phosphate | UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HeLa cell | - |
Homo sapiens | - |
| LoVo cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-N-acetyl-D-glucosamine + cathepsin D | substitution of two lysines (E203K/E267K) of the substrate cathepsin D stimulates mannose phosphorylation 116fold. Subtitution of additional residues in the beta loop particularly lysines, increase phosphorylation 4fold further | Homo sapiens | UMP + ? | - |
? | |
| UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose | initial enzyme in biosynthesis of mannose 6-phosphate | Homo sapiens | UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| N-acetylglucosamine-1-phosphotransferase | - |
Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
