Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.8.15 extracted from

  • Meyer, B.H.; Shams-Eldin, H.; Albers, S.V.
    AglH, a thermophilic UDP-N-acetylglucosamine-1-phosphate dolichyl phosphate GlcNAc-1-phosphotransferase initiating protein N-glycosylation pathway in Sulfolobus acidocaldarius, is capable of complementing the eukaryal Alg7 (2017), Extremophiles, 21, 121-134 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.8.15

Protein Variants

Protein Variants Comment Organism
D100A mutation of conserved amino acid in the putative cytoplasmic loop II, results in loss of function Sulfolobus acidocaldarius
D39A mutation in cytoplasmic loop I, no effect on function Sulfolobus acidocaldarius
F220A mutation of conserved amino acid in the putative cytoplasmic loops IV, results in loss of function Sulfolobus acidocaldarius
F264A mutation of conserved amino acid in the putative cytoplasmic loops V, results in loss of function Sulfolobus acidocaldarius
K218A mutation in cytoplasmic loop III, no effect on function Sulfolobus acidocaldarius
K42A mutation in cytoplasmic loop I, no effect on function Sulfolobus acidocaldarius
N103A mutation in cytoplasmic loop II, no effect on function Sulfolobus acidocaldarius

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane AglH possesses ten transmembrane helices separated by five internal and four external hydrophilic loops Sulfolobus acidocaldarius 16020
-

Organism

Organism UniProt Comment Textmining
Sulfolobus acidocaldarius P39465
-
-
Sulfolobus acidocaldarius ATCC 33909 P39465
-
-

Synonyms

Synonyms Comment Organism
AglH
-
 Sulfolobus acidocaldarius
GnpTA
-
 Sulfolobus acidocaldarius
saci0093
-
 Sulfolobus acidocaldarius
SACI_RS00435
-
 Sulfolobus acidocaldarius

General Information

General Information Comment Organism
physiological function AglH is essential for viability in Sulfolobus acidocaldarius. AglH is able to replace the endogenous GlcNAc-1-phosphotransferase activity of Alg7 in a conditional lethal Saccharomyces cerevisiae strain, in which the first step of the eukaryal protein N-glycosylation process is repressed Sulfolobus acidocaldarius