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Literature summary for 2.7.8.15 extracted from

  • Gao, N.; Shang, J.; Lehrman, M.A.
    Unexpected basis for impaired Glc3Man9GlcNAc2-P-P-dolichol biosynthesis by elevated expression of Glcnac-1-p transferase (2007), Glycobiology, 18, 125-134.
    View publication on PubMed
Search for more literature for 2.7.8.15

Inhibitors

Inhibitors Comment Organism Structure
GDP-mannose 5 residues of mannose from GDP-mannose Mesocricetus auratus
tunicamycin
-
 Mesocricetus auratus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome microsomal membranes Cricetulus griseus
-
-

Organism

Organism UniProt Comment Textmining
Cricetulus griseus
-
-
-
Mesocricetus auratus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CHO-K1 cell
-
 Cricetulus griseus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information overexpression of GPT in CHO-K1 cells does not go along with accumulation of intermediate Man5GlcNAc2-diphosphodolichol because of alteration of levels of oligosaccharide-diphosphodolichol and monosaccharide-phosphodolichol or through GPT enzymatic activity and excessive dolichyl phosphate consumption but rather may interfere with utilization of mannose- and glucosephosphodolichol Cricetulus griseus ?
-
 ?
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
-
 Mesocricetus auratus UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
 ?
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
-
 Cricetulus griseus UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol initiating subsequent synthesis of Glc3Man9GlcNAc2-diphosphodolichol ?

Synonyms

Synonyms Comment Organism
GlcNAc-1-P transferase
-
 Cricetulus griseus
GlcNAc-1-P transferase
-
 Mesocricetus auratus
GPT
-
 Cricetulus griseus
GPT
-
 Mesocricetus auratus