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Literature summary for 2.7.8.15 extracted from

  • Heifetz, A.; Keenan, R.W.; Elbein, A.D.
    Mechanism of action of tunicamycin on the UDP-GlcNAc:dolichyl-phosphate Glc-NAc-1-phosphate transferase (1979), Biochemistry, 18, 2186-2192.
    View publication on PubMed
Search for more literature for 2.7.8.15

Activating Compound

Activating Compound Comment Organism Structure
phosphatidylcholine 0.001 mM/ml, 30-40% inhibition Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
tunicamycin 0.00005-0.0001 mg/ml, 50% inhibition, noncompetitive with respect to UDP-GlcNAc or dolichyl phosphate, both directions Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0002
-
 UDP-GlcNAc 37°C Sus scrofa
0.0007
-
 dolichyl phosphate 37°C Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Sus scrofa
-
-

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
-
 Sus scrofa UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
 ?
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
-
 Sus scrofa UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
 r