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Literature summary for 2.7.8.11 extracted from
- Regulation of the PIS1-encoded phosphatidylinositol synthase in Saccharomyces cerevisiae by zinc (2005), J. Biol. Chem., 280, 29017-29024.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CDP-diacylglycerol + myo-inositol | Saccharomyces cerevisiae | phosphatidylinositol synthase activity increased when zinc is depleted from the growth medium. Analysis of a zrt1DELTA zrt2DELTA mutant defective in plasma membrane zinc transport indicates that the cytoplasmic levels of zinc are responsible for the regulation of phosphatidylinositol synthase. Regulation of PIS1 gene expression by zinc depletion is mediated by the zinc-regulated transcription factor Zap1p. Direct in-teraction between glutathione S-transferase (GST)-Zap1p 687880 and a putative upstream activating sequence (UAS) zinc-responsive element in the PIS1 | CMP + phosphatidyl-1D-myo-inositol | - |
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Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CDP-diacylglycerol + myo-inositol | - |
Saccharomyces cerevisiae | CMP + phosphatidyl-1D-myo-inositol | - |
? | |
| CDP-diacylglycerol + myo-inositol | phosphatidylinositol synthase activity increased when zinc is depleted from the growth medium. Analysis of a zrt1DELTA zrt2DELTA mutant defective in plasma membrane zinc transport indicates that the cytoplasmic levels of zinc are responsible for the regulation of phosphatidylinositol synthase. Regulation of PIS1 gene expression by zinc depletion is mediated by the zinc-regulated transcription factor Zap1p. Direct in-teraction between glutathione S-transferase (GST)-Zap1p 687880 and a putative upstream activating sequence (UAS) zinc-responsive element in the PIS1 | Saccharomyces cerevisiae | CMP + phosphatidyl-1D-myo-inositol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PIS1-encoded phosphatidylinositol synthase | - |
Saccharomyces cerevisiae |
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