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Literature summary for 2.7.8.1 extracted from
- PC and PE synthesis: mixed micellar analysis of the cholinephosphotransferase and ethanolaminephosphotransferase activities of human choline/ethanolamine phosphotransferase 1 (CEPT1) (2002), Lipids, 37, 663-672.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| chelerythrine | protein kinase C inhibitor, IC50 0.04 mM | Homo sapiens |  |
| R59949 | human DAG kinase inhibitor, IC50 0.04 mM | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.036 | - |
CDP-choline | 25°C, pH 8.0 | Homo sapiens | |
| 0.098 | - |
CDP-ethanolamine | 25°C, pH 8.0 | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
dual-specificity enzyme, activity of EC 2.7.8.1 and EC 2.7.8.2 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CDP-choline + 1,2-diacylglycerol | preferred substrates: di-18:1 diacylglycerol, di-16:1 diacylglycerol, 16:0/18:1 diacylglycerol | Homo sapiens | CMP + phosphatidylcholine | - |
? | |
| CDP-ethanolamine + 1,2-diacylglycerol | preferred substrates: 16:0/18:1 diacylglycerol, di-18:1 diacylglycerol | Homo sapiens | CMP + a phosphatidylethanolamine | - |
? | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.04 | - |
protein kinase C inhibitor, IC50 0.04 mM | Homo sapiens | chelerythrine | |
| 0.04 | - |
human DAG kinase inhibitor, IC50 0.04 mM | Homo sapiens | R59949 | |
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