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Literature summary for 2.7.7.97 extracted from
- Occurrence and biosynthesis of C-demethylactinomycins in actinomycin-producing Streptomyces chrysomallus and Streptomyces parvulus (2013), J. Antibiot., 66, 211-218.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 3-hydroxy-4-methylanthranilate | Streptomyces parvulus | - |
diphosphate + 3-hydroxy-4-methylanthranilyl-adenylate | - |
? |  |
| ATP + 3-hydroxy-4-methylanthranilate | Streptomyces anulatus | - |
diphosphate + 3-hydroxy-4-methylanthranilyl-adenylate | - |
? | |
| ATP + 3-hydroxy-4-methylanthranilate | Streptomyces parvulus ATCC 12434 | - |
diphosphate + 3-hydroxy-4-methylanthranilyl-adenylate | - |
? | |
| ATP + 3-hydroxy-4-methylanthranilate | Streptomyces anulatus ATCC 11523 | - |
diphosphate + 3-hydroxy-4-methylanthranilyl-adenylate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces anulatus | - |
- |
- |
| Streptomyces anulatus ATCC 11523 | - |
- |
- |
| Streptomyces parvulus | - |
- |
- |
| Streptomyces parvulus ATCC 12434 | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| mycelium | - |
Streptomyces parvulus | - |
| mycelium | - |
Streptomyces anulatus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 3-hydroxy-4-methylanthranilate | - |
Streptomyces parvulus | diphosphate + 3-hydroxy-4-methylanthranilyl-adenylate | - |
? | |
| ATP + 3-hydroxy-4-methylanthranilate | - |
Streptomyces anulatus | diphosphate + 3-hydroxy-4-methylanthranilyl-adenylate | - |
? | |
| ATP + 3-hydroxy-4-methylanthranilate | - |
Streptomyces parvulus ATCC 12434 | diphosphate + 3-hydroxy-4-methylanthranilyl-adenylate | - |
? | |
| ATP + 3-hydroxy-4-methylanthranilate | - |
Streptomyces anulatus ATCC 11523 | diphosphate + 3-hydroxy-4-methylanthranilyl-adenylate | - |
? | |
| ATP + 3-hydroxyanthranilic acid | much lower catalytic efficiency with 3-hydroxyanthranilic acid compared to 3-hydroxy-4-methylanthranilate | Streptomyces parvulus | ? | - |
? | |
| ATP + 3-hydroxyanthranilic acid | much lower catalytic efficiency with 3-hydroxyanthranilic acid compared to 3-hydroxy-4-methylanthranilate | Streptomyces anulatus | ? | - |
? | |
| ATP + 3-hydroxyanthranilic acid | much lower catalytic efficiency with 3-hydroxyanthranilic acid compared to 3-hydroxy-4-methylanthranilate | Streptomyces parvulus ATCC 12434 | ? | - |
? | |
| ATP + 3-hydroxyanthranilic acid | much lower catalytic efficiency with 3-hydroxyanthranilic acid compared to 3-hydroxy-4-methylanthranilate | Streptomyces anulatus ATCC 11523 | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 4-MHA activating enzyme | - |
Streptomyces parvulus |
| 4-MHA activating enzyme | - |
Streptomyces anulatus |
| ACMS I | - |
Streptomyces parvulus |
| ACMS I | - |
Streptomyces anulatus |
| actinomycin synthetase I | - |
Streptomyces parvulus |
| actinomycin synthetase I | - |
Streptomyces anulatus |
kcat/KM [mM/s]
| kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.3 | - |
3-hydroxyanthranilic acid | at 30°C, pH not specified in the publication | Streptomyces parvulus | |
| 0.3 | - |
3-hydroxyanthranilic acid | at 30°C, pH not specified in the publication | Streptomyces anulatus | |
| 7.8 | - |
3-hydroxy-4-methylanthranilate | at 30°C, pH not specified in the publication | Streptomyces parvulus | |
| 7.8 | - |
3-hydroxy-4-methylanthranilate | at 30°C, pH not specified in the publication | Streptomyces anulatus | |
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