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Literature summary for 2.7.7.88 extracted from

  • Ogino, T.; Banerjee, A.K.
    Formation of guanosine(5)tetraphospho(5)adenosine cap structure by an unconventional mRNA capping enzyme of vesicular stomatitis virus (2008), J. Virol., 82, 7729-7734.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.88

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
vesicular stomatitis Indiana virus P03523
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vesicular stomatitis Indiana virus San Juan P03523
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-triphospho-mRNA + GDP
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 vesicular stomatitis Indiana virus diphosphate + guanosine 5'-triphospho-mRNA enzyme produces a 5'-cap core structure, guanosine(5')triphospho(5')adenosine (GpppA), on viral mRNA ?
5'-triphospho-mRNA + GDP
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 vesicular stomatitis Indiana virus San Juan diphosphate + guanosine 5'-triphospho-mRNA enzyme produces a 5'-cap core structure, guanosine(5')triphospho(5')adenosine (GpppA), on viral mRNA ?
5'-triphospho-mRNA + GTP
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 vesicular stomatitis Indiana virus diphosphate + guanosine 5'-tetraphospho-mRNA additional reaction, the unusual cap structure guanosine(5')tetraphospho(5')adenosine (GppppA) is formed by the transfer of the 5'-monophosphorylated viral mRNA start sequence to GTP by the PRNTase activity before the removal of the gamma-phosphate from GTP by GTPase. GppppA-capped and polyadenylated full-length mRNAs are also synthesized by an in vitro transcription system ?
5'-triphospho-mRNA + GTP
-
 vesicular stomatitis Indiana virus San Juan diphosphate + guanosine 5'-tetraphospho-mRNA additional reaction, the unusual cap structure guanosine(5')tetraphospho(5')adenosine (GppppA) is formed by the transfer of the 5'-monophosphorylated viral mRNA start sequence to GTP by the PRNTase activity before the removal of the gamma-phosphate from GTP by GTPase. GppppA-capped and polyadenylated full-length mRNAs are also synthesized by an in vitro transcription system ?
additional information GppppA is efficiently formed on RNAs containing the ARCNG sequence. When GACAG RNA is used, no possible cap structures, such as GpppG and GppppG, are formed. AAGAG and ACGAA RNAs are obviously inert as substrates for GpppA formation with GTP as well as GDP vesicular stomatitis Indiana virus ?
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 ?
additional information GppppA is efficiently formed on RNAs containing the ARCNG sequence. When GACAG RNA is used, no possible cap structures, such as GpppG and GppppG, are formed. AAGAG and ACGAA RNAs are obviously inert as substrates for GpppA formation with GTP as well as GDP vesicular stomatitis Indiana virus San Juan ?
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 ?

Synonyms

Synonyms Comment Organism
PRNTase
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 vesicular stomatitis Indiana virus