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Literature summary for 2.7.7.86 extracted from

  • Diner, B.A.; Lum, K.K.; Toettcher, J.E.; Cristea, I.M.
    Viral DNA sensors IFI16 and cyclic GMP-AMP synthase possess distinct functions in regulating viral gene expression, immune defenses, and apoptotic responses during herpesvirus infection (2016), mBio, 7, e01553-16 .
    View publication on PubMedView publication on EuropePMC
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Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + GTP Homo sapiens overall reaction 2 diphosphate + cyclic Gp(2'-5')Ap(3'-5')
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 ?
additional information Homo sapiens interaction of cGAS and viral DNA sensor IFI16, the pyrin domain of IFI16 mediates the interaction with ND10 bodies and enzyme cGAS ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q8N884
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Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + GTP overall reaction Homo sapiens 2 diphosphate + cyclic Gp(2'-5')Ap(3'-5')
-
 ?
additional information interaction of cGAS and viral DNA sensor IFI16, the pyrin domain of IFI16 mediates the interaction with ND10 bodies and enzyme cGAS Homo sapiens ?
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Synonyms

Synonyms Comment Organism
cGAS
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 Homo sapiens

General Information

General Information Comment Organism
metabolism viral DNA sensors IFI16 and cyclic GMP-AMP synthase possess distinct functions in regulating viral gene expression, immune defenses, and apoptotic responses during herpesvirus infection. IFI16 is also proposed to stimulate other cellular pathways upon its binding to viral DNA. IFI16 is required for antiviral cytokine expression, but not for upstream activation of STING/TBK-1/IRF3 signaling Homo sapiens
physiological function the DNA sensor cyclic GMP-AMP synthase (cGAS) activates the canonical STING/TBK-1/IRF3 signaling axis including IFI16. Interferon-inducible protein 16 (IFI16) binds to DNA of nucleus-replicating herpesviruses and stimulates cytokine expression within infected nuclei. Recognition of viral DNA through DNA sensors is essential for the onset of antiviral responses during infection, mechanism, detailed overview. Analysis of distinct and cooperative functions of the DNA sensors IFI16 and cGAS in mediating antiviral responses to herpesviruses, i.e. HSV-1 and human cytomegalovirus (HCMV), overview. An HSV-1 mutant lacking the E3 ubiquitin ligase activity of the IE viral protein ICP0 from mutations in its ring finger domain (RF) is attenuated in its ability to induce IFI16 degradation.The pyrin domain of IFI16 mediates the interaction with ND10 bodies and cGAS. Of relevance to cellular immunity, both the antiviral ND10 body complex and the DNA sensor cGAS are PY-enriched associations during infection. ND10 body components include PML (promyelocytic leukemia protein), SUMO1, SUMO2, ATRX, SP110, and SP140L Homo sapiens