Cloned (Comment) | Organism |
---|---|
cloning from HeLa cells and analysis of the cGAS promoter region (-414 to +76 relative to the transcription start site), which is involved in the molecular mechanisms controlling the cGAS transcriptional activity, it is sufficient for promoter activity, RT-PCR enzyme expression analysis, transcription start site (TSS) localization of human cGAS (hcGAS) promoter | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | mutation of Sp1 and CREB binding sites in the cGAS promoter region leads to an apparent reduction of the cGAS promoter activity. Overexpression of Sp1 and CREB can enhance promoter activity, whereas knockdown of endogenous Sp1 and CREB markedly restrains the cGAS promoter activity. Transcription factors Sp1 and CREB regulate the transcription of the cGAS gene | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + GTP | Homo sapiens | overall reaction | 2 diphosphate + cyclic Gp(2'-5')Ap(3'-5') | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8N884 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + GTP | overall reaction | Homo sapiens | 2 diphosphate + cyclic Gp(2'-5')Ap(3'-5') | - |
? |
Synonyms | Comment | Organism |
---|---|---|
C6orf150 | chromosome 6 open reading frame 150 | Homo sapiens |
cGAMP synthase | - |
Homo sapiens |
cGAS | - |
Homo sapiens |
hcGAS | - |
Homo sapiens |
MB21D1 | MAB-21 domain-containing protein 1 | Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | knockdown of Sp1 and CREB by siRNA causes 70-80% and 60-70% decrease of protein levels | down |
Homo sapiens | transcription factors Sp1 and CREB regulate the transcription of the cGAS gene. Overexpression of Sp1 and CREB enhances the protein levels of cGAS by 2 and 2.5folds | up |
General Information | Comment | Organism |
---|---|---|
physiological function | cyclic GMP-AMP synthase (cGAS) plays crucial roles in autoimmune disease, anti-tumor response, anti-senescence and anti-inflammatory response | Homo sapiens |