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Literature summary for 2.7.7.86 extracted from

  • Chen, H.Y.; Pang, X.Y.; Xu, Y.Y.; Zhou, G.P.; Xu, H.G.
    Transcriptional regulation of human cyclic GMP-AMP synthase gene (2019), Cell. Signal., 62, 109355 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
cloning from HeLa cells and analysis of the cGAS promoter region (-414 to +76 relative to the transcription start site), which is involved in the molecular mechanisms controlling the cGAS transcriptional activity, it is sufficient for promoter activity, RT-PCR enzyme expression analysis, transcription start site (TSS) localization of human cGAS (hcGAS) promoter Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information mutation of Sp1 and CREB binding sites in the cGAS promoter region leads to an apparent reduction of the cGAS promoter activity. Overexpression of Sp1 and CREB can enhance promoter activity, whereas knockdown of endogenous Sp1 and CREB markedly restrains the cGAS promoter activity. Transcription factors Sp1 and CREB regulate the transcription of the cGAS gene Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + GTP Homo sapiens overall reaction 2 diphosphate + cyclic Gp(2'-5')Ap(3'-5')
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8N884
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-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
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Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + GTP overall reaction Homo sapiens 2 diphosphate + cyclic Gp(2'-5')Ap(3'-5')
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?

Synonyms

Synonyms Comment Organism
C6orf150 chromosome 6 open reading frame 150 Homo sapiens
cGAMP synthase
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Homo sapiens
cGAS
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Homo sapiens
hcGAS
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Homo sapiens
MB21D1 MAB-21 domain-containing protein 1 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens knockdown of Sp1 and CREB by siRNA causes 70-80% and 60-70% decrease of protein levels down
Homo sapiens transcription factors Sp1 and CREB regulate the transcription of the cGAS gene. Overexpression of Sp1 and CREB enhances the protein levels of cGAS by 2 and 2.5folds up

General Information

General Information Comment Organism
physiological function cyclic GMP-AMP synthase (cGAS) plays crucial roles in autoimmune disease, anti-tumor response, anti-senescence and anti-inflammatory response Homo sapiens