Literature summary for 2.7.7.86 extracted from

An, J.; Woodward, J.J.; Sasaki, T.; Minie, M.; Elkon, K.B.
Cutting edge: Antimalarial drugs inhibit IFN-beta production through blockade of cyclic GMP-AMP synthase-DNA interaction (2015), J. Immunol., 194, 4089-4093.

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Inhibitors

Inhibitors	Comment	Organism	Structure
9-amino-6-chloro-2-methoxyacridine	antimalarial drug, inhibits dsDNA stimulation of cGAS. IC50 value for interferon IFN-beta 0.0053 mM	Homo sapiens
Quinacrine	antimalarial drug, inhibits dsDNA stimulation of cGAS. IC50 value for interferon IFN-beta 0.0037 mM	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293T cell	-	Homo sapiens	-
THP-1 cell	-	Homo sapiens	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.013	-	pH 7.5, 22°C	Homo sapiens	Quinacrine
0.032	-	pH 7.5, 22°C	Homo sapiens	9-amino-6-chloro-2-methoxyacridine

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Release 2023.1 (January 2023)