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Literature summary for 2.7.7.86 extracted from

  • Storek, K.M.; Gertsvolf, N.A.; Ohlson, M.B.; Monack, D.M.
    cGAS and Ifi204 cooperate to produce type I IFNs in response to Francisella infection (2015), J. Immunol., 194, 3236-3245.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine cGAS and Ifi204 cooperate to sense cytosolic dsDNA and rancisella. novicida infection to produce a strong type I IFN response Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
macrophage primary and immortalized murine macrophages Mus musculus
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RAW-264.7 cell
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 Mus musculus
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General Information

General Information Comment Organism
physiological function cyclic GMP-AMP synthase cGAS and interferon activated gene Ifi204, are both required for the STING-dependent type I IFN response to Francisella novicida infection. cGAS and Ifi204 cooperate to sense dsDNA and activate the STING-dependent type I IFN pathway. dsDNA from Francisella novicida is an important type I IFN stimulating ligand. cGAS–STING signaling leads to activation of the absent in melanoma 2 inflammasome in response to Francisella novicida infection. The absent in melanoma 2 inflammasome is beneficial to the host during Francisella novicida infection, type I IFN signaling by STING and IFN regulatory factor 3 is detrimental to the host Mus musculus