Literature summary for 2.7.7.86 extracted from

Zhang, Y.; Yeruva, L.; Marinov, A.; Prantner, D.; Wyrick, P.B.; Lupashin, V.; Nagarajan, U.M.
The DNA sensor, cyclic GMP-AMP synthase, is essential for induction of IFN-beta during Chlamydia trachomatis infection (2014), J. Immunol., 193, 2394-2404.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	upon infection with Chlamydia trachomatis cGAS localizes in punctate regions on the cytosolic side of the chlamydial inclusion membrane in association with stimulator of genes STING	Homo sapiens	16020	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q8N884	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293T cell	-	Homo sapiens	-
HeLa cell	-	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	cGAS is required for IFN-beta expression during chlamydial infection in multiple cell types. Although infected cells deficient for STING or cGAS alone fail to induce IFN-beta, coculture of cells depleted for either STING or cGAS rescues IFN-beta expression. Cyclic GMP-AMP produced in infected cGAS(+)STING(-) cells can migrate into adjacent cells via gap junctions to function in trans in cGAS(-)STING(+) cells	Homo sapiens

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Release 2023.1 (January 2023)