Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.7.86 extracted from

  • Andrade, W.A.; Agarwal, S.; Mo, S.; Shaffer, S.A.; Dillard, J.P.; Schmidt, T.; Hornung, V.; Fitzgerald, K.A.; Kurt-Jones, E.A.; Golenbock, D.T.
    Type I interferon induction by Neisseria gonorrhoeae: dual Requirement of cyclic GMP-AMP synthase and toll-like receptor 4 (2016), Cell Rep., 15, 2438-2448.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine complete interferon IFN-beta induction by live Neisseria gonorrhoeae depends on both cGAS and toll-like receptor TLR4. Type I IFN is detrimental to the host, and dysregulation of iron homeostasis genes may explain lower bacteria survival in cGAS-/- and TLR4-/- cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8N884
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
Homo sapiens
-

General Information

General Information Comment Organism
physiological function type I interferon induction by Neisseria gonorrhoeae infection Is dependent on cGAS, but not PYHIN family member IFI16. Complete activation of IFN-beta by Neisseria gonorrhoeae infection is an additive effect of both cGAS/stimulator of IFN genes STING and toll-like receptor TLR4 pathways. cGAMP is induced after GC infection and GC DNA transfection Homo sapiens