Literature summary for 2.7.7.86 extracted from

Collins, A.C.; Cai, H.; Li, T.; Franco, L.H.; Li, X.D.; Nair, V.R.; Scharn, C.R.; Stamm, C.E.; Levine, B.; Chen, Z.J.; Shiloh, M.U.
Cyclic GMP-AMP synthase is an innate immune DNA sensor for Mycobacterium tuberculosis (2015), Cell Host Microbe, 17, 820-828.

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Application

Application	Comment	Organism
medicine	Mycobacterium tuberculosis activates cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase cGAS in macrophages to produce cGAMP, that activates the adaptor protein stimulator of interferon genes STING to induce type I interferons and other cytokines	Homo sapiens
medicine	Mycobacterium tuberculosis activates cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase cGAS in macrophages to produce cGAMP, that activates the adaptor protein stimulator of interferon genes STING to induce type I interferons and other cytokines	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q8N884	-	-
Mus musculus	Q8C6L5	-	-

Synonyms

Synonyms	Comment	Organism
MB21D1	-	Homo sapiens
MB21D1	-	Mus musculus

General Information

General Information	Comment	Organism
physiological function	Mycobacterium tuberculosis activates cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase cGAS in macrophages to produce cGAMP. cGAS localizes with Mycobacterium tuberculosis in human cells and in human tuberculosis lesions. Knockdown or knockout of cGAS in blocks cytokine production and induction of autophagy	Homo sapiens
physiological function	Mycobacterium tuberculosis activates cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase cGAS in macrophages to produce cGAMP. cGAS localizes with Mycobacterium tuberculosis in mice cells. Knockdown or knockout of cGAS in blocks cytokine production and induction of autophagy. Mice deficient in cGAS are more susceptible to lethality caused by infection with Mycobacterium tuberculosis	Mus musculus

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Release 2023.1 (January 2023)