Application | Comment | Organism |
---|---|---|
medicine | Mycobacterium tuberculosis activates cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase cGAS in macrophages to produce cGAMP, that activates the adaptor protein stimulator of interferon genes STING to induce type I interferons and other cytokines | Homo sapiens |
medicine | Mycobacterium tuberculosis activates cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase cGAS in macrophages to produce cGAMP, that activates the adaptor protein stimulator of interferon genes STING to induce type I interferons and other cytokines | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8N884 | - |
- |
Mus musculus | Q8C6L5 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
MB21D1 | - |
Homo sapiens |
MB21D1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | Mycobacterium tuberculosis activates cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase cGAS in macrophages to produce cGAMP. cGAS localizes with Mycobacterium tuberculosis in human cells and in human tuberculosis lesions. Knockdown or knockout of cGAS in blocks cytokine production and induction of autophagy | Homo sapiens |
physiological function | Mycobacterium tuberculosis activates cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase cGAS in macrophages to produce cGAMP. cGAS localizes with Mycobacterium tuberculosis in mice cells. Knockdown or knockout of cGAS in blocks cytokine production and induction of autophagy. Mice deficient in cGAS are more susceptible to lethality caused by infection with Mycobacterium tuberculosis | Mus musculus |