Literature summary for 2.7.7.86 extracted from

Ablasser, A.; Schmid-Burgk, J.L.; Hemmerling, I.; Horvath, G.L.; Schmidt, T.; Latz, E.; Hornung, V.
Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP (2013), Nature, 503, 530-534.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in HEK-293 cells	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + GTP	Homo sapiens	-	2 diphosphate + cyclic Gp(2'-5')Ap(3'-5')	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q8N884	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + GTP	-	Homo sapiens	2 diphosphate + cyclic Gp(2'-5')Ap(3'-5')	-	?

Synonyms

Synonyms	Comment	Organism
cGAS	-	Homo sapiens
cyclic GMP-AMP synthase	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	enzyme overexpression induces spontaneous activation of STING and IRF3 phosphorylation in bystander cells	Homo sapiens

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Release 2023.1 (January 2023)