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Literature summary for 2.7.7.86 extracted from

  • Sun, L.; Wu, J.; Du, F.; Chen, X.; Chen, Z.J.
    Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway (2013), Science, 339, 786-791.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.86

Activating Compound

Activating Compound Comment Organism Structure
DNA the cyclase activity is stimulated by DNA but not by RNA Homo sapiens
DNA the cyclase activity is stimulated by DNA but not by RNA Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK293T cells Homo sapiens
expressed in HEK293T cells and expressed in Escherichia coli as a SUMO (small ubiquitin-related modifier protein) fusion protein Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-
cytosol
-
 Mus musculus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + GTP Homo sapiens cyclic 3',5'-AMP-GMP is a signalling molecule in mammalian cells that triggers the production of type I interferons and other cytokines 2 diphosphate + cyclic 3',5'-AMP-GMP
-
 ?
ATP + GTP Mus musculus cyclic 3',5'-AMP-GMP is a signalling molecule in mammalian cells that triggers the production of type I interferons and other cytokines 2 diphosphate + cyclic 3',5'-AMP-GMP
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8N884
-
-
Mus musculus Q8C6L5
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens
-
 Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + GTP
-
 Homo sapiens 2 diphosphate + cyclic 3',5'-AMP-GMP
-
 ?
ATP + GTP
-
 Mus musculus 2 diphosphate + cyclic 3',5'-AMP-GMP
-
 ?
ATP + GTP cyclic 3',5'-AMP-GMP is a signalling molecule in mammalian cells that triggers the production of type I interferons and other cytokines Homo sapiens 2 diphosphate + cyclic 3',5'-AMP-GMP
-
 ?
ATP + GTP cyclic 3',5'-AMP-GMP is a signalling molecule in mammalian cells that triggers the production of type I interferons and other cytokines Mus musculus 2 diphosphate + cyclic 3',5'-AMP-GMP
-
 ?

Synonyms

Synonyms Comment Organism
cGAMP synthase
-
 Homo sapiens
cGAMP synthase
-
 Mus musculus
cGAS
-
 Homo sapiens
cGAS
-
 Mus musculus