Literature summary for 2.7.7.85 extracted from

Dengler, V.; McCallum, N.; Kiefer, P.; Christen, P.; Patrignani, A.; Vorholt, J.A.; Berger-Baechi, B.; Senn, M.M.
Mutation in the C-di-AMP cyclase dacA affects fitness and resistance of methicillin resistant Staphylococcus aureus (2013), PLoS ONE, 8, e73512.

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Protein Variants

Protein Variants	Comment	Organism
G206S	single nucleotide polymorphism identified in in a faster growing but less resistant strain of an isogenic MRSA strain pair that differs in methicillin resistance levels and fitness	Staphylococcus aureus

Organism

Organism	UniProt	Comment	Textmining
Staphylococcus aureus	Q2FW92	-	-
Staphylococcus aureus NCTC 8325	Q2FW92	-	-

Synonyms

Synonyms	Comment	Organism
dacA	-	Staphylococcus aureus
SAOUHSC_02407	-	Staphylococcus aureus

General Information

General Information	Comment	Organism
physiological function	introduction of single nucleotide polymorphism G206S into an isogenic highly resistant but slower growing strain reduces resistance and increases its growth rate, suggesting a direct connection between the dacA mutation and the phenotypic differences of these strains. The dacA mutation decreases cyclic di-AMP levels resulting in reduced autolysis, increased salt tolerance and a reduction in the basal expression of the cell wall stress stimulon	Staphylococcus aureus

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Release 2023.1 (January 2023)