Literature summary for 2.7.7.85 extracted from

Witte, C.E.; Whiteley, A.T.; Burke, T.P.; Sauer, J.D.; Portnoy, D.A.; Woodward, J.J.
Cyclic di-AMP is critical for Listeria monocytogenes growth, cell wall homeostasis, and establishment of infection (2013), mBio, 4, e00282-13.

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Organism

Organism	UniProt	Comment	Textmining
Listeria monocytogenes	-	-	-

Synonyms

Synonyms	Comment	Organism
dacA	-	Listeria monocytogenes

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Listeria monocytogenes

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8	-	assay at	Listeria monocytogenes

General Information

General Information	Comment	Organism
malfunction	reduction of cyclic di-3',5'-adenylate levels by conditional depletion of the di-adenylate cyclase DacA leads to marked decreases in growth rates, both in vitro and in macrophages. Conditional depletion of dacA also leads to increased IFN-beta expression and a concomitant increase in host cell pyroptosis, a result of increased bacteriolysis and subsequent bacterial DNA release	Listeria monocytogenes
physiological function	cyclic di-3',5'-adenylate coordinates bacterial growth, cell wall stability, and responses to stress and plays a crucial role in the establishment of bacterial infection	Listeria monocytogenes

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Release 2023.1 (January 2023)