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Literature summary for 2.7.7.85 extracted from

  • Mehne, F.M.; Gunka, K.; Eilers, H.; Herzberg, C.; Kaever, V.; Stuelke, J.
    Cyclic di-AMP homeostasis in Bacillus subtilis: both lack and high level accumulation of the nucleotide are detrimental for cell growth (2013), J. Biol. Chem., 288, 2004-2017.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
cdaA and cdaS genes are cloned into the expression vector pET28a, expression in Escherichia coli Bacillus subtilis

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
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Bacillus subtilis 168
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Synonyms

Synonyms Comment Organism
CdaA
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 Bacillus subtilis
CdaS
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 Bacillus subtilis

General Information

General Information Comment Organism
physiological function the signaling nucleotide cyclic di-3',5'-adenylate is essential for the viability of Bacillus subtilis. However, excess cyclic di-3',5'-adenylate also harms the cells. The activity of the cyclases is subject to regulation. The activity of the diadenylate cyclases is controlled by distinct molecular mechanisms. Isoenzyme CdaA is stimulated by a regulatory interaction with the CdaR protein. In contrast, the activity of CdaS seems to be intrinsically restricted, and a single amino acid substitution is sufficient to drastically increase the activity of the enzyme Bacillus subtilis