Protein Variants | Comment | Organism |
---|---|---|
additional information | enzyme OAS1 knockdown by siRNA, or overexpression in Marc-145 cells. Three siRNAs are designed according to the published Macaque OAS1 mRNA sequence (Macaca mulatta, UniProt ID A4LAA0). Knockdown of OAS1 by siRNA significantly increases the frequency of CPE of PRRSV in Marc-145 cells | Chlorocebus sabaeus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Chlorocebus sabaeus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3 ATP | Chlorocebus sabaeus | - |
pppA2'p5'A2'p5'A + 2 diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Chlorocebus sabaeus | A0A0D9S3Y6 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Marc-145 cell | - |
Chlorocebus sabaeus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3 ATP | - |
Chlorocebus sabaeus | pppA2'p5'A2'p5'A + 2 diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
2',5'-oligoadenylate synthetase 1 | - |
Chlorocebus sabaeus |
OAS1 | - |
Chlorocebus sabaeus |
Organism | Comment | Expression |
---|---|---|
Chlorocebus sabaeus | porcine reproductive and respiratory syndrome virus (PRRSV) infection leads to induction of 2',5'-oligoadenylate synthetase gene 1 (OAS1), an important interferon-stimulated gene | up |
General Information | Comment | Organism |
---|---|---|
malfunction | knockdown of endogenous OAS1 increases the PRRSV ORF7 mRNA level to 1.6 and 1.7times of that in control in 24 and 36 hours post-infection of PRRSV, respectively, and leads to approximate 5.5times increase of the frequency of fluorescence positive cells compared to negative control. Overexpression of OAS1 in Marc-145 cells can inhibit the replication of PRRSV | Chlorocebus sabaeus |
physiological function | 2',5'-oligoadenylate synthetase 1 (OAS1) inhibits PRRSV replication in monkey Marc-145 cells. Antiviral activity of OAS1 has been demonstrated in mice and humans with infections of numerous RNA and DNA viruses, such as coxsackie virus, West Nile virus, Hepatitis C virus, cowpox virus, and SARS virus | Chlorocebus sabaeus |