Literature summary for 2.7.7.84 extracted from

Kajaste-Rudnitski, A.; Mashimo, T.; Frenkiel, M.; Guenet, J.; Lucas, M.; Despres, P.
The 2',5'oligoadenylate synthetase 1b is a potent inhibitor of West Nile virus replication inside infected cells (2006), J. Biol. Chem., 281, 4624-4637.

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Cloned(Commentary)

Cloned (Comment)	Organism
stable Oas1b protein overexpression under the control of the Tet-Off expression system in a mouse fibroblastic cell line, MEF/3T3.Tet-Off. The murine cells respond to Oas1b expression by efficiently inhibiting WNV viral replication	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	gene oas1b encoding isozyme Oas1b	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
2',5'oligoadenylate synthetase 1b	-	Mus musculus
OAS	-	Mus musculus

Expression

Organism	Comment	Expression
Mus musculus	induction by interferon	up

General Information

General Information	Comment	Organism
physiological function	The 2,5'-oligoadenylate synthetase proteins associated with endoribonuclease RNase L are components of the interferon-regulated OAS/RNase L system, which is an RNA decay pathway known to play an important role in the innate antiviral immunity. Critical role for the 1b isoform of the mouse Oas1b gene in resistance to West Nile virus, WNV, infection in vivo, molecular basis for the sensitivity of WNVto the Oas1b antiviral pathway, overview. Antiviral action of Oas1b is essentially restricted to the early stages in virus life cycle. Inability of WNV to productively infect the Oas1b-expressing cells is attributable to a dramatic reduction in positive-stranded viral RNA level	Mus musculus

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Release 2023.1 (January 2023)