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Literature summary for 2.7.7.84 extracted from
- Inhibition of 2'-5' oligoadenylate synthetase by divalent metal ions (2001), FEBS Lett., 507, 54-58.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| dsRNA | the catalysis of 2'-5'-oligoadenylate synthesis is strictly dependent on double-stranded RNA and magnesium ions | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| functional expression of p42 isoform of OAS1 and the p69 isoform of OAS2 in insect cells | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | moderate inhibition | Homo sapiens |  |
| Cu2+ | strong inhibition | Homo sapiens | |
| Fe2+ | strong inhibition | Homo sapiens | |
| Ni2+ | moderate inhibition | Homo sapiens | |
| Zn2+ | strong inhibition, zinc ions can control the oligomerisation by enhancing the formation of tetrameric forms of OAS1p42 | Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | the catalysis of 2'-5'-oligoadenylate synthesis is strictly dependent on double-stranded RNA and magnesium ions | Homo sapiens | |
| Mn2+ | activates, can substitute for Mg2+ | Homo sapiens | |
| additional information | the enzyme activity is not affected by Ca2+ ions | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3 ATP | Homo sapiens | - |
pppA2'p5'A2'p5'A + 2 diphosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
p42 isoform of OAS1 and the p69 isoform of OAS2 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3 ATP | - |
Homo sapiens | pppA2'p5'A2'p5'A + 2 diphosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | zinc ions can control the oligomerisation by enhancing the formation of tetrameric forms of OAS1p42 | Homo sapiens |
| tetramer | - |
Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 2'-5' oligoadenylate synthetase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | inhibition kinetics with Zn2+ | Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.021 | - |
OAS2p69, pH 7.5, 37°C | Homo sapiens | Zn2+ | |
| 0.099 | - |
OAS1p42, pH 7.5, 37°C | Homo sapiens | Zn2+ | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | induction by interferon | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| additional information | OAS1 is the small form and OAS2 is the medium form of the human interferon-induced 2'-5'-oligoadenylate synthases | Homo sapiens |
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