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Literature summary for 2.7.7.8 extracted from

  • Sarkar, D.; Park, E.S.; Barber, G.N.; Fisher, P.B.
    Activation of double-stranded RNA dependent protein kinase, a new pathway by which human polynucleotide phosphorylase (hPNPase(old-35)) induces apoptosis (2007), Cancer Res., 67, 7948-7953.
    View publication on PubMed

Application

Application Comment Organism
medicine the apoptosis-inducing activity of polynucleotide phosphorylase is mediated by activation of double-stranded RNA-dependent protein kinase. Activation of RNA-dependent protein kinase by polynucleotide phosphorylase precedes phosphorylation of eukaryotic initiation factor-2A and induction of growth arrest and DNA damage-inducible gene 153, GADD153, that culminates in the shutdown of protein synthesis and apoptosis. Activation of RNA-dependent protein kinase by polynucleotide phosphorylase also instigates down-regulation of the antiapoptotic protein Bcl-xL. A dominant-negative inhibitor of RNA-dependent protein kinase, as well as GADD153 antisense or bcl-xL overexpression, effectively inhibits apoptosis induction by polynucleotide phosphorylase Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the apoptosis-inducing activity of polynucleotide phosphorylase is mediated by activation of double-stranded RNA–dependent protein kinase. Activation of RNA-dependent protein kinase by polynucleotide phosphorylase precedes phosphorylation of eukaryotic initiation factor-2A and induction of growth arrest and DNA damage-inducible gene 153, GADD153, that culminates in the shutdown of protein synthesis and apoptosis. Activation of RNA-dependent protein kinase by polynucleotide phosphorylase also instigates down-regulation of the antiapoptotic protein Bcl-xL ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the apoptosis-inducing activity of polynucleotide phosphorylase is mediated by activation of double-stranded RNA–dependent protein kinase. Activation of RNA-dependent protein kinase by polynucleotide phosphorylase precedes phosphorylation of eukaryotic initiation factor-2A and induction of growth arrest and DNA damage-inducible gene 153, GADD153, that culminates in the shutdown of protein synthesis and apoptosis. Activation of RNA-dependent protein kinase by polynucleotide phosphorylase also instigates down-regulation of the antiapoptotic protein Bcl-xL Homo sapiens ?
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