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Literature summary for 2.7.7.7 extracted from

  • Tang, X.; Shen, Y.; Matsui, E.; Matsui, I.
    Domain topology of the DNA polymerase D complex from a hyperthermophilic archaeon Pyrococcus horikoshii (2004), Biochemistry, 43, 11818-11827 .
    View publication on PubMed
Search for more literature for 2.7.7.7

Cloned(Commentary)

Cloned (Comment) Organism
expression of proteins from large subunit DP2(1-100), large subunit DP2(792-1163), and small subunit DP1(1-200) Pyrococcus horikoshii

Organism

Organism UniProt Comment Textmining
Pyrococcus horikoshii O57863 and O57861 O57863: DNA polymerase II small subunit, gene name polB, ordered locus name: PH0123, O57861: DNA polymerase II large subunit, gene name polC, ordered locus name: PH0121
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Pyrococcus horikoshii OT-3 O57863 and O57861 O57863: DNA polymerase II small subunit, gene name polB, ordered locus name: PH0123, O57861: DNA polymerase II large subunit, gene name polC, ordered locus name: PH0121
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Purification (Commentary)

Purification (Comment) Organism
-
 Pyrococcus horikoshii

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn the yeast two-hybrid system is employed to define regions of intermolecular interaction between small subunit DP1, large subunit DP2, and proliferating cell nuclear antigen PCNA. Intra- and intermolecular interactions between these domains are verified by using surface plasmon resonance Pyrococcus horikoshii diphosphate + DNAn+1
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 ?
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn the yeast two-hybrid system is employed to define regions of intermolecular interaction between small subunit DP1, large subunit DP2, and proliferating cell nuclear antigen PCNA. Intra- and intermolecular interactions between these domains are verified by using surface plasmon resonance Pyrococcus horikoshii OT-3 diphosphate + DNAn+1
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 ?

Subunits

Subunits Comment Organism
heterotetramer heterotetramer L2S2 with two large subunits (DP2) and two small subunits (DP1) Pyrococcus horikoshii

Synonyms

Synonyms Comment Organism
DNA polymerase D
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 Pyrococcus horikoshii
PH0121 ordered locus name of DNA polymerase II large subunit Pyrococcus horikoshii
PH0123 ordered locus name of DNA polymerase II small subunit Pyrococcus horikoshii
polD
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 Pyrococcus horikoshii