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Literature summary for 2.7.7.7 extracted from

  • Xu, C.; Maxwell, B.A.; Brown, J.A.; Zhang, L.; Suo, Z.
    Global conformational dynamics of a Y-family DNA polymerase during catalysis (2009), PLoS Biol., 7, e1000225.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Saccharolobus solfataricus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn the binding of a correct nucleotide induces a fast and surprising DNA translocation event. All four domains of the polymerase rapidly move in a synchronized manner before and after the polymerization reaction. Repositioning of active site residues is the rate-limiting step during correct nucleotide incorporation. The motions of the polymerase and the polymerase bound DNA substrate are tightly coupled to catalysis Saccharolobus solfataricus diphosphate + DNAn+1
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Synonyms

Synonyms Comment Organism
DNA polymerase IV
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Saccharolobus solfataricus
Dpo4
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Saccharolobus solfataricus