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Literature summary for 2.7.7.7 extracted from

  • Potapova, O.; Grindley, N.D.; Joyce, C.M.
    The mutational specificity of the Dbh lesion bypass polymerase and its implications (2002), J. Biol. Chem., 277, 28157-28166.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
deoxynucleoside triphosphate + DNAn Saccharolobus solfataricus
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diphosphate + DNAn+1
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?

Organism

Organism UniProt Comment Textmining
Saccharolobus solfataricus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn
-
Saccharolobus solfataricus diphosphate + DNAn+1
-
?
deoxynucleoside triphosphate + DNAn Dbh polymerase is much less accurate than the classical polymerases, but it shows a remarkable tendency to skip over a template pyrimidine positioned immediately 3' to a G residue, generating a single-base deletion. The rate of incorporation of dCTP opposite a template G is about 10fold faster than for the other three dNTPs opposite their complementary partners Saccharolobus solfataricus diphosphate + DNAn+1
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?

Synonyms

Synonyms Comment Organism
Dbh polymerase
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Saccharolobus solfataricus