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Literature summary for 2.7.7.7 extracted from

  • Wu, Y.; Wilson, R.C.; Pata, J.D.
    The Y-family DNA polymerase Dpo4 uses a template slippage mechanism to create single-base deletions (2011), J. Bacteriol., 193, 2630-2636.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
crystals are grown at room temperature by hanging drop vapor diffusion Saccharolobus solfataricus

Organism

Organism UniProt Comment Textmining
Saccharolobus solfataricus Q97W02
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Saccharolobus solfataricus P2 Q97W02
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn Dpo4 predominantly uses a template slippage deletion mechanism when replicating repetitive DNA sequences. Dpo4 stabilizes the skipped template base in an extrahelical conformation between the polymerase and the little-finger domains of the enzyme Saccharolobus solfataricus diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn Dpo4 predominantly uses a template slippage deletion mechanism when replicating repetitive DNA sequences. Dpo4 stabilizes the skipped template base in an extrahelical conformation between the polymerase and the little-finger domains of the enzyme Saccharolobus solfataricus P2 diphosphate + DNAn+1
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Synonyms

Synonyms Comment Organism
DNA polymerase Dpo4
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Saccharolobus solfataricus