Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-chloro-1,4-dihydro-4-oxo-1-(beta-D-ribofuranosyl) quinoline-3-carboxylic acid | noncompetitive inhibitor | Human alphaherpesvirus 1 | |
6-chloro-1,4-dihydro-4-oxo-1H-quinoline-3-carboxylic acid | - |
Human alphaherpesvirus 1 | |
acyclovir triphosphate | - |
Human alphaherpesvirus 1 | |
aphidicolin | - |
Human alphaherpesvirus 1 |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Human alphaherpesvirus 1 | - |
- |
- |
Purification (Comment) | Organism |
---|---|
partially purified from HSV-1-infected Vero cells, DEAE-cellulose column chromatography, and phosphate cellulose column chromatography | Human alphaherpesvirus 1 |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
deoxynucleoside triphosphate + DNAn | - |
Human alphaherpesvirus 1 | diphosphate + DNAn+1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DNA polymerase | - |
Human alphaherpesvirus 1 |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0001 | - |
6-chloro-1,4-dihydro-4-oxo-1-(beta-D-ribofuranosyl) quinoline-3-carboxylic acid | in 50 mM Tris-HCl (pH 8.0), 8 mM MgCl2, and 0.5 mM dithiohtreitol, at 37°C | Human alphaherpesvirus 1 | |
0.0002 | - |
6-chloro-1,4-dihydro-4-oxo-1H-quinoline-3-carboxylic acid | in 50 mM Tris-HCl (pH 8.0), 8 mM MgCl2, and 0.5 mM dithiohtreitol, at 37°C | Human alphaherpesvirus 1 | |
0.0003 | - |
aphidicolin | in 50 mM Tris-HCl (pH 8.0), 8 mM MgCl2, and 0.5 mM dithiohtreitol, at 37°C | Human alphaherpesvirus 1 | |
0.0004 | - |
acyclovir triphosphate | in 50 mM Tris-HCl (pH 8.0), 8 mM MgCl2, and 0.5 mM dithiohtreitol, at 37°C | Human alphaherpesvirus 1 |