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Literature summary for 2.7.7.7 extracted from
- The properties of steric gate mutants reveal different constraints within the active sites of Y-family and A-family DNA polymerases (2006), J. Biol. Chem., 281, 27286-27291.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sulfolobus acidocaldarius | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| deoxynucleoside triphosphate + DNAn | the flexibility on the template side of the Dbh active site allows for a consistent location of the incoming dNTP regardless of whether or not it is correctly paired with its templating partner. Contact of the dNTP sugar with the Phe12 steric gate side chain is maintained in all circumstances with the result that Dbh shows stringent discrimination against ribonucleotides but does not use the steric gate side chain as a discriminator against nascent mispairs | Sulfolobus acidocaldarius | diphosphate + DNAn+1 | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DBH | - |
Sulfolobus acidocaldarius |
| DinB homologue | - |
Sulfolobus acidocaldarius |
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Release 2023.1 (January 2023)
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