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Literature summary for 2.7.7.7 extracted from

  • Fujii, S.; Gasser, V.; Fuchs, R.P.
    The biochemical requirements of DNA polymerase V-mediated translesion synthesis revisited (2004), J. Mol. Biol., 341, 405-417.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information two factors are essential for efficient Pol V-mediated lesion bypass: 1. a DNA substrate onto which the beta-clamp is stably loaded and 2. an extended single-stranded RecA/ATP filament assembled downstream from the lesion site. For efficient bypass, Pol V needs to interact simultaneously with the beta-clamp and the 3' tip of the RecA filament Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
deoxynucleoside triphosphate + DNAn Escherichia coli DNA polymerase V is involved in translesion synthesis and mutagenesis diphosphate + DNAn+1
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?

Organism

Organism UniProt Comment Textmining
Escherichia coli
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn DNA polymerase V is involved in translesion synthesis and mutagenesis Escherichia coli diphosphate + DNAn+1
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?
deoxynucleoside triphosphate + DNAn DNA polymerase V is involved in translesion synthesis and mutagenesis. Two factors are essential for efficient Pol V-mediated lesion bypass: 1. a DNA substrate onto which the beta-clamp is stably loaded and 2. an extended single-stranded RecA/ATP filament assembled downstream from the lesion site. For efficient bypass, Pol V needs to interact simultaneously with the beta-clamp and the 3' tip of the RecA filament Escherichia coli diphosphate + DNAn+1
-
?

Synonyms

Synonyms Comment Organism
DNA polymerase V
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Escherichia coli