Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.7.7 extracted from

  • Lehman, R.
    DNA polymerase I of Escherichia coli (1981), The Enzymes,3rd Ed. (Boyer,P. D. ,ed. ), 14, 15-37.
No PubMed abstract available
Search for more literature for 2.7.7.7

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
 Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ pol I contains one Zn2+ per molecule Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
109000
-
 pol I Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
deoxynucleoside triphosphate + DNAn Escherichia coli physiological role of pol I diphosphate + DNAn+1
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 pol I
-

Reaction

Reaction Comment Organism Reaction ID
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1 mechanism Escherichia coli
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time, cannot initiate a chain de novo, requires a primer which may be DNA or RNA Escherichia coli diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn exonuclease 3'--5' activity, pol I Escherichia coli diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn exonuclease 5'--3' activity, pol I Escherichia coli diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn physiological role of pol I Escherichia coli diphosphate + DNAn+1
-
 ?

Subunits

Subunits Comment Organism
monomer 1 * 109000, pol I Escherichia coli