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Literature summary for 2.7.7.65 extracted from

  • Petrova, O.E.; Cherny, K.E.; Sauer, K.
    The Pseudomonas aeruginosa diguanylate cyclase GcbA, a homolog of P. fluorescens GcbA, promotes initial attachment to surfaces, but not biofilm formation, via regulation of motility (2014), J. Bacteriol., 196, 2827-2841.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
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Pseudomonas fluorescens
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Synonyms

Synonyms Comment Organism
GcbA
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 Pseudomonas fluorescens
GcbA
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 Pseudomonas aeruginosa

General Information

General Information Comment Organism
physiological function enzyme synthesizes cyclic-di-GMP to regulate surface attachment via modulation of motility, without affecting subsequent biofilm formation. GcbA regulates flagellum-driven motility by suppressing flagellar reversal rates in a manner independent of viscosity, surface hardness, and polysaccharide production Pseudomonas aeruginosa
physiological function Pseudomonas fluorescens GcbA is functional in P.seudomonas aeruginosa and is capable of restoring phenotypes associated with inactivation of gcbA in P.seudomonas aeruginosa to wild-type levels. Motility and attachment of a gcbA mutant strain can be restored to wild-type levels via overexpression of the small regulatory RNA RsmZ. While both contribute to the regulation of initial surface attachment and flagellum-driven motility, GcbA and the phosphodiesterase DipA act within different signaling networks to regulate these processes Pseudomonas fluorescens