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Literature summary for 2.7.7.65 extracted from

  • Chaudhuri, S.; Pratap, S.; Paromov, V.; Li, Z.; Mantri, C.K.; Xie, H.
    Identification of a diguanylate cyclase and its role in Porphyromonas gingivalis virulence (2014), Infect. Immun., 82, 2728-2735.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Porphyromonas gingivalis B2RM56
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Porphyromonas gingivalis DSM 20709 B2RM56
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Subunits

Subunits Comment Organism
More protein PGN_1932 contains a GGDEF domain Porphyromonas gingivalis

Synonyms

Synonyms Comment Organism
PGN_1932
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Porphyromonas gingivalis

General Information

General Information Comment Organism
physiological function a deletion mutation in the pgn_1932 gene has a significant effect on the intracellular cyclic-di-GMP level in Porphyromonas gingivalis. Expression of the fimA and rgpA genes, encoding the major protein subunit of fimbriae and an arginine-specific proteinase, respectively, is downregulated in the pgn_1932 mutant. Correspondingly, FimA protein production and the fimbrial display on the mutant are significantly reduced. Mutations in the pgn_1932 gene also have a significant impact on the adhesive and invasive capabilities of P.orphyromonas gingivalis, which are required for its pathogenicity Porphyromonas gingivalis