Organism | UniProt | Comment | Textmining |
---|---|---|---|
Porphyromonas gingivalis | B2RM56 | - |
- |
Porphyromonas gingivalis DSM 20709 | B2RM56 | - |
- |
Subunits | Comment | Organism |
---|---|---|
More | protein PGN_1932 contains a GGDEF domain | Porphyromonas gingivalis |
Synonyms | Comment | Organism |
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PGN_1932 | - |
Porphyromonas gingivalis |
General Information | Comment | Organism |
---|---|---|
physiological function | a deletion mutation in the pgn_1932 gene has a significant effect on the intracellular cyclic-di-GMP level in Porphyromonas gingivalis. Expression of the fimA and rgpA genes, encoding the major protein subunit of fimbriae and an arginine-specific proteinase, respectively, is downregulated in the pgn_1932 mutant. Correspondingly, FimA protein production and the fimbrial display on the mutant are significantly reduced. Mutations in the pgn_1932 gene also have a significant impact on the adhesive and invasive capabilities of P.orphyromonas gingivalis, which are required for its pathogenicity | Porphyromonas gingivalis |