Organism | UniProt | Comment | Textmining |
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Vibrio cholerae serotype O1 | - |
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- |
Vibrio cholerae serotype O1 C6706str2 | - |
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Synonyms | Comment | Organism |
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VCA0965 | - |
Vibrio cholerae serotype O1 |
General Information | Comment | Organism |
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physiological function | ectopic expression of VCA0965 in ibrio. cholerae causes a 3fold reduction in flagellar-based motility. An RXXD allosteric inhibition mutant of VCA0965 strongly inhibits motility and stimulates biofilm formation. This activity is lost when the active site of VCA0965 is mutated to AGDAF, suggesting that VCA0965 synthesizes cyclic-di-GMP. Ectopic expression of VCA0965 and VCA0965 containing a mutation in its RXXD motif significantly increases the intracellular cyclic-di-GMP levels in Vibrio cholerae and Escherichia coli. Purified VCA0965 is able to synthesize cyclic-di-GMP in vitro | Vibrio cholerae serotype O1 |