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Literature summary for 2.7.7.65 extracted from

  • Kostick, J.L.; Szkotnicki, L.T.; Rogers, E.A.; Bocci, P.; Raffaelli, N.; Marconi, R.T.
    The diguanylate cyclase, Rrp1, regulates critical steps in the enzootic cycle of the Lyme disease spirochetes (2011), Mol. Microbiol., 81, 219-231.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Borreliella burgdorferi
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-
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Synonyms

Synonyms Comment Organism
diguanylate cyclase
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 Borreliella burgdorferi
Rrp1
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 Borreliella burgdorferi

General Information

General Information Comment Organism
malfunction Borrelia burgdorferi strains that lack Rrp1 or that constitutively produce elevated levels of Rrp1 are generated and analyzed for their ability to infect and transit between mice and Ixodes ticks. Rrp1, and by extension, c-di-GMP, are not required for murine infection, but are required for the successful establishment of a productive population of Borrelia burgdorferi in ticks Borreliella burgdorferi