Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.7.65 extracted from

  • Kuchma, S.L.; Brothers, K.M.; Merritt, J.H.; Liberati, N.T.; Ausubel, F.M.; O'Toole, G.A.
    BifA, a cyclic-Di-GMP phosphodiesterase, inversely regulates biofilm formation and swarming motility by Pseudomonas aeruginosa PA14 (2007), J. Bacteriol., 189, 8165-8178.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli with His-tag Pseudomonas aeruginosa

Protein Variants

Protein Variants Comment Organism
additional information deletion of gene PA4367 results in severe defect in swarming motility and a hyperbiofilm phenotype. Mutant exhibits increased cellular pools of cyclic di-3’,5’-guanylate, increased synthesis of a polysaccharide produced by the pel locus and decreased flagellar reversals. GGDQF and EAL domains of BifA are both required for complementation of the mutant Pseudomonas aeruginosa

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane inner membrane Pseudomonas aeruginosa 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
78000
-
x * 78000, calculated Pseudomonas aeruginosa

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
-
strain PA14, gene PA4367 encodes a protein with an EAL domain associated with cyclic di-3'5'-guanylate phosphodiesterase activity, and a DDGEF domain associated with cyclic di-di-3'5'-guanylate cyclase activity
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information purified enzyme shows phosphodiesterase activity, but no diguanylate cyclase activity Pseudomonas aeruginosa ?
-
?

Subunits

Subunits Comment Organism
? x * 78000, calculated Pseudomonas aeruginosa

Synonyms

Synonyms Comment Organism
BifA
-
Pseudomonas aeruginosa
PA4367
-
Pseudomonas aeruginosa