Literature summary for 2.7.7.62 extracted from

Thompson, T.B.; Thomas, M.G.; Escalante-Semerena, J.C.; Rayment, I.
Three-dimensional structure of adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltransferase (CobU) complexed with GMP: evidence for a substrate-induced transferase active site (1999), Biochemistry, 38, 12995-13005.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
X-ray crystal structure determined by molecular replacement to 2.2 A resolution, crystals grown by the batch method, cocrystallized with GTP and diphosphate, crystals belong to space group P2(1)2(1)2(1) with unit cell dimensions a : 58.4 A, b : 87.8 A, and c : 101.6 A	Salmonella enterica subsp. enterica serovar Typhimurium

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
19000	-	3 * 19000, homotrimer	Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
GTP + adenosylcobinamide phosphate	Salmonella enterica subsp. enterica serovar Typhimurium	biosynthesis of cobalamin, enzyme catalyzes the phosphorylation of the 1-amino-O-2-propanol side chain of the adenosylcobinamide ring	diphosphate + adenosylcobinamide-GDP	-	?

Organism

Organism	UniProt	Comment	Textmining
Salmonella enterica subsp. enterica serovar Typhimurium	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Salmonella enterica subsp. enterica serovar Typhimurium

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GTP + adenosylcobinamide phosphate	-	Salmonella enterica subsp. enterica serovar Typhimurium	diphosphate + adenosylcobinamide-GDP	-	?
GTP + adenosylcobinamide phosphate	biosynthesis of cobalamin, enzyme catalyzes the phosphorylation of the 1-amino-O-2-propanol side chain of the adenosylcobinamide ring	Salmonella enterica subsp. enterica serovar Typhimurium	diphosphate + adenosylcobinamide-GDP	-	?
additional information	CobU is a bifunctional enzyme that has both kinase EC 2.7.1.156 and guanyltransferase EC 2.7.7.62 activities	Salmonella enterica subsp. enterica serovar Typhimurium	?	-	?

Subunits

Subunits	Comment	Organism
trimer	3 * 19000, homotrimer	Salmonella enterica subsp. enterica serovar Typhimurium

Synonyms

Synonyms	Comment	Organism
adenosylcobinamide phosphate guanyltransferase	-	Salmonella enterica subsp. enterica serovar Typhimurium
CobU	-	Salmonella enterica subsp. enterica serovar Typhimurium

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Release 2023.1 (January 2023)