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Literature summary for 2.7.7.60 extracted from

  • Obiol-Pardo, C.; Cordero, A.; Rubio-Martinez, J.; Imperial, S.
    Homology modeling of Mycobacterium tuberculosis 2C-methyl-D-erythritol-4-phosphate cytidylyltransferase, the third enzyme in the MEP pathway for isoprenoid biosynthesis (2010), J. Mol. Model., 16, 1061-1073.
    View publication on PubMed
Search for more literature for 2.7.7.60

Application

Application Comment Organism
medicine the structure of CMS of Mycobacterium tuberculosis could be a starting point for structure-based design of new antituberculosis drugs Mycobacterium tuberculosis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.043
-
 2-C-methyl-D-erythritol 4-phosphate calculated affinity Mycobacterium tuberculosis
0.092
-
 CTP calculated affinity Mycobacterium tuberculosis

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Mycobacterium tuberculosis
Mn2+
-
 Mycobacterium tuberculosis
Zn2+
-
 Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CTP + 2-C-methyl-D-erythritol 4-phosphate Mycobacterium tuberculosis
-
 diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
 ?
CTP + 2-C-methyl-D-erythritol 4-phosphate Mycobacterium tuberculosis H37Rv
-
 diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WKG9
-
-
Mycobacterium tuberculosis H37Rv P9WKG9
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CTP + 2-C-methyl-D-erythritol 4-phosphate
-
 Mycobacterium tuberculosis diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
 ?
CTP + 2-C-methyl-D-erythritol 4-phosphate
-
 Mycobacterium tuberculosis H37Rv diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
 ?

Synonyms

Synonyms Comment Organism
2C-methyl-D-erythritol-4-phosphate cytidylyltransferase
-
 Mycobacterium tuberculosis
CMS
-
 Mycobacterium tuberculosis

pH Range

pH Minimum pH Maximum Comment Organism
6 9
-
 Mycobacterium tuberculosis

General Information

General Information Comment Organism
physiological function 2C-methyl-D-erythritol-4-phosphate cytidylyltransferase is the third enzyme in the MEP pathway for isoprenoid biosynthesis Mycobacterium tuberculosis