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Literature summary for 2.7.7.6 extracted from

  • Koo, C.X.; Kobiyama, K.; Shen, Y.J.; LeBert, N.; Ahmad, S.; Khatoo, M.; Aoshi, T.; Gasser, S.; Ishii, K.J.
    RNA polymerase III regulates cytosolic RNA:DNA hybrids and intracellular microRNA expression (2015), J. Biol. Chem., 290, 7463-7473.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.6

Protein Variants

Protein Variants Comment Organism
additional information for genetic inhibition of Pol III, A549 cells are transfected with siRNA against POLR3G (siPOLR3G_1 and siPOLR3G_2), a subunit of the Pol III complex, or negative control siRNA Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
ML-60218 treatment of A-549 cells with the Pol III inhibitor ML-60218 decreased the cytosolic RNA:DNA hybrid staining Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-
mitochondrion
-
 Homo sapiens 5739
-
nucleus Pol III is present mostly in the nucleus Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
pol III
-
 Homo sapiens
PolIII
-
 Homo sapiens
RNA polymerase III
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function RNA polymerase III regulates the presence of cytosolic RNA:DNA hybrids and miRNA biogenesis in various human cells. RNA:DNA hybrids exist in the cytosol of various human cells and are mediated by RNA polymerase III, which regulates the microRNA machinery, cytosolic RNA:DNA hybrids may have physiological relevance to miRNA machinery and RNA transport, miRNA expression analysis, RNA transport and mRNA surveillance pathways are potential targets of Pol III-modulated miRNAs, overview. Inhibition of the DNA damage response has no effect on the presence of RNA:DNA hybrids in the cytosol, and the levels of cytosolic RNA:DNA hybrids are not modulated by genotoxic replication inhibitors Homo sapiens