Literature summary for 2.7.7.6 extracted from

Klein-Marcuschamer, D.; Santos, C.N.; Yu, H.; Stephanopoulos, G.
Mutagenesis of the bacterial RNA polymerase alpha subunit for improvement of complex phenotypes (2009), Appl. Environ. Microbiol., 75, 2705-2711.

Search for more literature for 2.7.7.6

Cloned(Commentary)

Cloned (Comment)	Organism
gene rpoA, library screening	Escherichia coli K-12

Protein Variants

Protein Variants	Comment	Organism
E244stop	random mutagenesis, identification of mutant L33, a truncated protein that lacks the C-terminal alpha-subunit, alphaCTD, but is capable of being assembled into the RNAP and carrying out transcription, while it does not respond to signals in the DNA or from protein effectors, overview. The mutant grows faster and exhibits a higher accumulated cell mass than the wild-type in the presence of butanol, phenotype, overview	Escherichia coli K-12
V257F/L281P	random mutagenesis, the rpoA14 mutant shows mutations of the C-terminal alpha-subunit, phenotype, overview	Escherichia coli K-12
V257R	random mutagenesis, the rpoA22 mutant shows a mutation of the C-terminal alpha-subunit, phenotype, overview	Escherichia coli K-12

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli K-12	-	several strains, gene rpoA	-

Synonyms

Synonyms	Comment	Organism
RNA polymerase	-	Escherichia coli K-12
RNAP	-	Escherichia coli K-12

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Release 2023.1 (January 2023)