Literature summary for 2.7.7.59 extracted from

Nolden, L.; Ngouoto-Nkili, C.E.; Bendt, A.K.; Kramer, R.; Burkovski, A.
Sensing nitrogen limitation in Corynebacterium glutamicum: the role of glnK and glnD (2001), Mol. Microbiol., 42, 1281-1295.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression of glnD in a deficient mutant strain restores the constitutive enzyme, complementation	Corynebacterium glutamicum
gene glnD, construction of chromosomal deletion mutant	Corynebacterium glutamicum

Protein Variants

Protein Variants	Comment	Organism
additional information	deletion mutant is impaired in its response to nitrogen shortage, mutant shows reduced growth rate in presence of limiting amounts of ammonium or urea, deletion also impairs the transcription of genes amtB and glnK within the same operon	Corynebacterium glutamicum
additional information	a GlnKY51F protein mutant strain shows no enzyme expression, irrespective of the nitrogen status	Corynebacterium glutamicum

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
UTP + [protein-GlnK]	Corynebacterium glutamicum	uridylylation of GlnK protein is essential for the cell to respond to nitrogen limitation	diphosphate + uridylyl-[protein-GlnK]	-	?
UTP + [protein-PII]	Corynebacterium glutamicum	unlike in enterobacteria, the enzyme is not the primary nitrogen sensor, overexpression leads to derepression of nitrogen control	diphosphate + uridylyl-[protein-PII]	-	?
UTP + [protein-PII]	Corynebacterium glutamicum	signal transduction cascade model	diphosphate + uridylyl-[protein-PII]	-	?

Organism

Organism	UniProt	Comment	Textmining
Corynebacterium glutamicum	Q9X706	expression is upregulated upon nitrogen limitation	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
UTP + [protein-GlnK]	GlnK protein mutant Y51F is no substrate	Corynebacterium glutamicum	diphosphate + uridylyl-[protein-GlnK]	-	?
UTP + [protein-GlnK]	uridylylation of GlnK protein is essential for the cell to respond to nitrogen limitation	Corynebacterium glutamicum	diphosphate + uridylyl-[protein-GlnK]	-	?
UTP + [protein-PII]	-	Corynebacterium glutamicum	diphosphate + uridylyl-[protein-PII]	-	?
UTP + [protein-PII]	unlike in enterobacteria, the enzyme is not the primary nitrogen sensor, overexpression leads to derepression of nitrogen control	Corynebacterium glutamicum	diphosphate + uridylyl-[protein-PII]	-	?
UTP + [protein-PII]	signal transduction cascade model	Corynebacterium glutamicum	diphosphate + uridylyl-[protein-PII]	-	?

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Release 2023.1 (January 2023)