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Literature summary for 2.7.7.56 extracted from

  • Bowden, K.; Wiese, N.; Perwez, T.; Mohanty, B.; Kushner, S.
    The rph-1-encoded truncated RNase PH protein inhibits RNase P maturation of pre-tRNAs with short leader sequences in the absence of RppH (2017), J. Bacteriol., 199, e00301 .
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Escherichia coli P0CG19 naturally acquired truncated inactive ribonuclease PH variant
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Synonyms

Synonyms Comment Organism
Rph-1
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Escherichia coli

General Information

General Information Comment Organism
physiological function laboratory strains MG1655 and W3110 have naturally acquired the Rph-1 allele, encoding a truncated catalytically inactive RNase PH protein. Rph-1 protein inhibits RNase P-mediated 5'-end maturation of primary pre-tRNAs with leaders of less than 5 nucleotides in the absence of RppH, an RNA diphosphohydrolase. RppH is not required for 5'-end maturation of endonucleolytically generated pre-tRNAs in the Rph-1 strain and for any tRNAs in Rph mutant or Rp+x03 strains Escherichia coli