BRENDA - Enzyme Database
show all sequences of 2.7.7.53

Purification and functional characterization of diadenosine 5,5'-P(1),P(4)-tetraphosphate phosphorylases from Mycobacterium smegmatis and Mycobacterium avium

Honda, N.; Kim, H.; Rimbara, E.; Kato, A.; Shibayama, K.; Mori, S.; Protein Expr. Purif. 112, 37-42 (2015)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
-
Mycolicibacterium smegmatis
expression in Escherichia coli
Mycobacterium avium
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Ca2+
2 mM, 38% of the activity with Mn2+
Mycobacterium avium
Ca2+
2 mM, 43% of the activity with Mn2+
Mycolicibacterium smegmatis
Co2+
2 mM, 89% of the activity with Mn2+
Mycobacterium avium
Co2+
2 mM, 60% of the activity with Mn2+
Mycolicibacterium smegmatis
Mg2+
2 mM, 98% of the activity with Mn2+
Mycobacterium avium
Mg2+
2 mM, 97% of the activity with Mn2+
Mycolicibacterium smegmatis
Mn2+
2 mM, best divalent activator
Mycobacterium avium
Mn2+
2 mM, best divalent activator
Mycolicibacterium smegmatis
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
22500
-
x * 22500, calculated
Mycolicibacterium smegmatis
24500
-
-
Mycobacterium avium
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Mycobacterium avium
A0A0H3A0T9
-
-
Mycobacterium avium 104
A0A0H3A0T9
-
-
Mycolicibacterium smegmatis
A0QWG3
-
-
Mycolicibacterium smegmatis ATCC 700084
A0QWG3
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
P1,P3-bis(5'-adenosyl) triphosphate + phosphate
14% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycobacterium avium
2 ADP
major product
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate + phosphate
26% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycolicibacterium smegmatis
2 ADP
major product
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate + phosphate
14% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycobacterium avium 104
2 ADP
major product
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate + phosphate
26% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycolicibacterium smegmatis ATCC 700084
2 ADP
major product
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
-
739577
Mycolicibacterium smegmatis
ADP + ATP
no formation of AMP observed
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
-
739577
Mycobacterium avium
ADP + ATP
no formation of AMP observed
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
-
739577
Mycobacterium avium 104
ADP + ATP
no formation of AMP observed
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
-
739577
Mycolicibacterium smegmatis ATCC 700084
ADP + ATP
no formation of AMP observed
-
-
?
P1,P4-bis(5'-guanosyl) tetraphosphate + phosphate
53% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycobacterium avium
GDP + GTP
major products
-
-
?
P1,P4-bis(5'-guanosyl) tetraphosphate + phosphate
56% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycolicibacterium smegmatis
GDP + GTP
major products
-
-
?
P1,P4-bis(5'-guanosyl) tetraphosphate + phosphate
53% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycobacterium avium 104
GDP + GTP
major products
-
-
?
P1,P4-bis(5'-guanosyl) tetraphosphate + phosphate
56% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycolicibacterium smegmatis ATCC 700084
GDP + GTP
major products
-
-
?
P1,P5-bis(5'-adenosyl) pentaphosphate + phosphate
44% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycolicibacterium smegmatis
?
-
-
-
?
P1,P5-bis(5'-adenosyl) pentaphosphate + phosphate
47% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycobacterium avium
?
-
-
-
?
P1,P5-bis(5'-adenosyl) pentaphosphate + phosphate
47% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycobacterium avium 104
?
-
-
-
?
P1,P5-bis(5'-adenosyl) pentaphosphate + phosphate
44% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycolicibacterium smegmatis ATCC 700084
?
-
-
-
?
P1,P5-bis(5'-guanosyl) pentaphosphate + phosphate
49% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycolicibacterium smegmatis
p4G + GDP
major products
-
-
?
P1,P5-bis(5'-guanosyl) pentaphosphate + phosphate
55% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycobacterium avium
p4G + GDP
major products
-
-
?
P1-(5'-adenosyl)-P4-(5'-deoxythymidyl) tetraphosphate + phosphate
68% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycobacterium avium
ATP + dTDP
or ADP + dTTP, major products
-
-
?
P1-(5'-adenosyl)-P5-(5'-deoxythymidyl) pentaphosphate + phosphate
30% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycolicibacterium smegmatis
p4A + dTDP
or ADP + p4dT, major products
-
-
?
P1-(5'-adenosyl)-P5-(5'-guanosyl) pentaphosphate + phosphate
49% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycobacterium avium
p4A + GDP
major products
-
-
?
P1-(5'-adenosyl)P4-(5'-deoxythymidyl) pentaphosphate + phosphate
31% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycobacterium avium
p4A + dTDP
or ADP + p4dT, major products
-
-
?
P1-(5'-adenosyl)P4-(5'-deoxythymidyl) tetraphosphate + phosphate
85% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycolicibacterium smegmatis
ATP + dTDP
or ADP + dTTP, major products
-
-
?
P1-(5'-adenosyl)P4-(5'-guanosyl) pentaphosphate + phosphate
30% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycolicibacterium smegmatis
p4A + GDP
major products
-
-
?
P1-(5'-adenosyl)P4-(5'-guanosyl) tetraphosphate + phosphate
80% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycolicibacterium smegmatis
ATP + GDP
or ADP plus GTP, major products
-
-
?
P1-(5'-adenosyl)P4-(5'-guanosyl) tetraphosphate + phosphate
93% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycobacterium avium
ATP + GDP
or ADP plus GTP, major products
-
-
?
P1-(5'-adenosyl)P4-(5'-guanosyl) tetraphosphate + phosphate
93% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycobacterium avium 104
ATP + GDP
or ADP plus GTP, major products
-
-
?
P1-(5'-adenosyl)P4-(5'-guanosyl) tetraphosphate + phosphate
80% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycolicibacterium smegmatis ATCC 700084
ATP + GDP
or ADP plus GTP, major products
-
-
?
Subunits
Subunits
Commentary
Organism
?
x * 24500, calculated
Mycobacterium avium
?
x * 22500, calculated
Mycolicibacterium smegmatis
Cloned(Commentary) (protein specific)
Commentary
Organism
-
Mycolicibacterium smegmatis
expression in Escherichia coli
Mycobacterium avium
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Ca2+
2 mM, 38% of the activity with Mn2+
Mycobacterium avium
Ca2+
2 mM, 43% of the activity with Mn2+
Mycolicibacterium smegmatis
Co2+
2 mM, 89% of the activity with Mn2+
Mycobacterium avium
Co2+
2 mM, 60% of the activity with Mn2+
Mycolicibacterium smegmatis
Mg2+
2 mM, 98% of the activity with Mn2+
Mycobacterium avium
Mg2+
2 mM, 97% of the activity with Mn2+
Mycolicibacterium smegmatis
Mn2+
2 mM, best divalent activator
Mycobacterium avium
Mn2+
2 mM, best divalent activator
Mycolicibacterium smegmatis
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
22500
-
x * 22500, calculated
Mycolicibacterium smegmatis
24500
-
-
Mycobacterium avium
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
P1,P3-bis(5'-adenosyl) triphosphate + phosphate
14% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycobacterium avium
2 ADP
major product
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate + phosphate
26% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycolicibacterium smegmatis
2 ADP
major product
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate + phosphate
14% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycobacterium avium 104
2 ADP
major product
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate + phosphate
26% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycolicibacterium smegmatis ATCC 700084
2 ADP
major product
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
-
739577
Mycolicibacterium smegmatis
ADP + ATP
no formation of AMP observed
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
-
739577
Mycobacterium avium
ADP + ATP
no formation of AMP observed
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
-
739577
Mycobacterium avium 104
ADP + ATP
no formation of AMP observed
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
-
739577
Mycolicibacterium smegmatis ATCC 700084
ADP + ATP
no formation of AMP observed
-
-
?
P1,P4-bis(5'-guanosyl) tetraphosphate + phosphate
53% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycobacterium avium
GDP + GTP
major products
-
-
?
P1,P4-bis(5'-guanosyl) tetraphosphate + phosphate
56% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycolicibacterium smegmatis
GDP + GTP
major products
-
-
?
P1,P4-bis(5'-guanosyl) tetraphosphate + phosphate
53% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycobacterium avium 104
GDP + GTP
major products
-
-
?
P1,P4-bis(5'-guanosyl) tetraphosphate + phosphate
56% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycolicibacterium smegmatis ATCC 700084
GDP + GTP
major products
-
-
?
P1,P5-bis(5'-adenosyl) pentaphosphate + phosphate
44% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycolicibacterium smegmatis
?
-
-
-
?
P1,P5-bis(5'-adenosyl) pentaphosphate + phosphate
47% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycobacterium avium
?
-
-
-
?
P1,P5-bis(5'-adenosyl) pentaphosphate + phosphate
47% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycobacterium avium 104
?
-
-
-
?
P1,P5-bis(5'-adenosyl) pentaphosphate + phosphate
44% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycolicibacterium smegmatis ATCC 700084
?
-
-
-
?
P1,P5-bis(5'-guanosyl) pentaphosphate + phosphate
49% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycolicibacterium smegmatis
p4G + GDP
major products
-
-
?
P1,P5-bis(5'-guanosyl) pentaphosphate + phosphate
55% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycobacterium avium
p4G + GDP
major products
-
-
?
P1-(5'-adenosyl)-P4-(5'-deoxythymidyl) tetraphosphate + phosphate
68% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycobacterium avium
ATP + dTDP
or ADP + dTTP, major products
-
-
?
P1-(5'-adenosyl)-P5-(5'-deoxythymidyl) pentaphosphate + phosphate
30% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycolicibacterium smegmatis
p4A + dTDP
or ADP + p4dT, major products
-
-
?
P1-(5'-adenosyl)-P5-(5'-guanosyl) pentaphosphate + phosphate
49% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycobacterium avium
p4A + GDP
major products
-
-
?
P1-(5'-adenosyl)P4-(5'-deoxythymidyl) pentaphosphate + phosphate
31% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycobacterium avium
p4A + dTDP
or ADP + p4dT, major products
-
-
?
P1-(5'-adenosyl)P4-(5'-deoxythymidyl) tetraphosphate + phosphate
85% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycolicibacterium smegmatis
ATP + dTDP
or ADP + dTTP, major products
-
-
?
P1-(5'-adenosyl)P4-(5'-guanosyl) pentaphosphate + phosphate
30% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycolicibacterium smegmatis
p4A + GDP
major products
-
-
?
P1-(5'-adenosyl)P4-(5'-guanosyl) tetraphosphate + phosphate
80% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycolicibacterium smegmatis
ATP + GDP
or ADP plus GTP, major products
-
-
?
P1-(5'-adenosyl)P4-(5'-guanosyl) tetraphosphate + phosphate
93% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycobacterium avium
ATP + GDP
or ADP plus GTP, major products
-
-
?
P1-(5'-adenosyl)P4-(5'-guanosyl) tetraphosphate + phosphate
93% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycobacterium avium 104
ATP + GDP
or ADP plus GTP, major products
-
-
?
P1-(5'-adenosyl)P4-(5'-guanosyl) tetraphosphate + phosphate
80% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
739577
Mycolicibacterium smegmatis ATCC 700084
ATP + GDP
or ADP plus GTP, major products
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 24500, calculated
Mycobacterium avium
?
x * 22500, calculated
Mycolicibacterium smegmatis
Other publictions for EC 2.7.7.53
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737871
Mori
Roles of Ala-149 in the cataly ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Biosci. Biotechnol. Biochem.
79
236-238
2015
-
-
-
-
1
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
12
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
12
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
739577
Honda
Purification and functional ch ...
Mycobacterium avium 104, Mycobacterium avium, Mycolicibacterium smegmatis, Mycolicibacterium smegmatis ATCC 700084
Protein Expr. Purif.
112
37-42
2015
-
-
2
-
-
-
-
-
-
8
2
-
-
7
-
-
-
-
-
-
-
-
28
2
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
8
2
-
-
-
-
-
-
-
-
-
28
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
722980
Mori
Structural insights into the n ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
J. Mol. Biol.
410
93-104
2011
-
-
1
1
8
-
-
4
-
-
-
-
-
5
-
-
-
-
-
-
-
-
2
-
-
-
-
5
-
-
-
-
-
-
-
-
-
1
-
1
8
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
5
-
-
-
-
-
-
-
-
5
5
713455
Mori
Purification and molecular cha ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Protein Expr. Purif.
69
99-105
2010
-
-
1
-
-
-
-
2
-
4
2
-
-
6
-
-
1
-
-
-
2
-
14
1
1
-
1
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
2
-
4
2
-
-
-
-
1
-
-
2
-
14
1
1
-
1
-
1
1
-
-
-
-
-
-
-
-
643515
McLennan
Anabaena flos-aquae and other ...
Dolichospermum flos-aquae, Synechococcus sp., Trichormus variabilis
Biochem. J.
320
795-800
1996
-
-
-
-
-
-
-
1
-
5
3
-
-
10
-
-
1
-
-
-
1
-
13
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
5
3
-
-
-
-
1
-
-
1
-
13
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
289064
Guranowski
-
Methylene and halomethylene an ...
Acanthamoeba castellanii
Nucleosides Nucleotides
14
731-734
1995
-
-
-
-
-
-
2
4
-
-
-
-
-
1
-
-
1
-
-
-
-
-
11
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
2
2
4
-
-
-
-
-
-
-
1
-
-
-
-
11
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
643514
Booth
An alleged yeast polyphosphate ...
Saccharomyces cerevisiae
J. Biol. Chem.
270
19377-19382
1995
-
-
-
-
-
-
3
-
-
1
1
-
-
2
-
-
-
-
-
-
-
-
7
1
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3
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1
1
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7
1
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209909
McLennan
The green alga Scenedesmus obl ...
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-
5
1
25
1
5
-
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-
6
1
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-
-
-
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1
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7
-
7
2
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1
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-
5
1
25
1
5
-
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6
1
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643509
Avila
Immunoaffinity chromatography ...
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1
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1
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6
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1
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1
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1
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1
-
6
-
1
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643513
Guranowski
Specific phosphorylase from Eu ...
Acanthamoeba castellanii, Euglena gracilis
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1988
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-
-
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3
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2
1
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2
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1
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13
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1
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3
-
2
1
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1
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13
-
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-
1
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-
246767
Guranowski
Phosphonate analogues of diade ...
Saccharomyces cerevisiae
Biochemistry
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3425-3429
1987
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1
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1
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3
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1
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1
1
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-
3
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643508
Brevet
Yeast diadenosine 5,5-P1,P4-te ...
Saccharomyces cerevisiae
Biochemistry
26
4763-4768
1987
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-
-
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1
2
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6
-
1
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2
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7
-
1
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2
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1
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2
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6
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1
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7
-
1
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2
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643510
Guranowski
Diadenosine 5,5-P1, P4-tetraph ...
Saccharomyces cerevisiae
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261
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1986
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2
8
4
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2
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2
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4
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1
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1
4
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2
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8
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4
-
2
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4
-
1
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1
4
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643507
Guranowski
Phosphorolytic cleavage of dia ...
Saccharomyces cerevisiae
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3542-3547
1985
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1
4
3
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8
1
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1
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1
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1
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10
1
1
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1
1
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1
-
4
-
3
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8
1
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1
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1
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10
1
1
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1
1
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