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Literature summary for 2.7.7.52 extracted from

  • Kim, H.; Kim, J.; Yu, S.; Lee, Y.Y.; Park, J.; Choi, R.J.; Yoon, S.J.; Kang, S.G.; Kim, V.N.
    A mechanism for microRNA arm switching regulated by uridylation (2020), Mol. Cell, 78, 1224-1236 .
    View publication on PubMed
Search for more literature for 2.7.7.52

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UTP + miR-324n Homo sapiens
-
 diphosphate + miR-324n+1
-
 ?
UTP + miRNAn Homo sapiens
-
 diphosphate + miRNAn+1
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q5TAX3
-
-
Homo sapiens Q5VYS8
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain low activity Homo sapiens
-
glioblastoma cell high activity Homo sapiens
-
HEK-293T cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UTP + miR-324n
-
 Homo sapiens diphosphate + miR-324n+1
-
 ?
UTP + miRNAn
-
 Homo sapiens diphosphate + miRNAn+1
-
 ?

Synonyms

Synonyms Comment Organism
terminal uridylyltransferase
-
 Homo sapiens
TUT4 isoform Homo sapiens
TUT7 isoform Homo sapiens

General Information

General Information Comment Organism
physiological function isoform TUT4 uridylates pre-miR-324, resulting in alternative processing by DICER. The altered cleavage leads to selection of the 3p strand instead of the 5p strand. Perturbation of the miR-324 arm usage disrupts glioblastoma cell proliferation Homo sapiens
physiological function isoform TUT7 uridylates pre-miR-324, resulting in alternative processing by DICER. The altered cleavage leads to selection of the 3p strand instead of the 5p strand. Perturbation of the miR-324 arm usage disrupts glioblastoma cell proliferation Homo sapiens