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Literature summary for 2.7.7.52 extracted from

  • Yashiro, Y.; Tomita, K.
    Function and regulation of human terminal uridylyltransferases (2018), Front. Genet., 9, 538 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.52

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UTP + RNAn Homo sapiens the enzyme mediates template-independent uridylylation at the 3'-end of RNAs diphosphate + RNAn+1
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens F5H0R1
-
-
Homo sapiens Q5TAX3
-
-
Homo sapiens Q5VYS8
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + U6 small nuclear RNA isoform TUT1 incorporates UMP more efficiently than AMP into U6 small nuclear RNA transcript ending with four uridines Homo sapiens ?
-
 ?
UTP + precursor let-7 RNA
-
 Homo sapiens ?
-
 ?
UTP + RNAn the enzyme mediates template-independent uridylylation at the 3'-end of RNAs Homo sapiens diphosphate + RNAn+1
-
 ?
UTP + U6 small nuclear RNA isoform TUT1 incorporates UMP more efficiently than AMP into U6 small nuclear RNA transcript ending with four uridines Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
terminal uridylyltransferase
-
 Homo sapiens
TUT1 isoform Homo sapiens
TUT4 isoform Homo sapiens
TUT7 isoform Homo sapiens
TUTase
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism isoform TUT1 catalyzes oligo-uridylylation of U6 small nuclear RNA, which catalyzes mRNA splicing. Oligo-uridylylation of U6 snRNA is required for U6 snRNA maturation, U4/U6-di-snRNP formation, and U6 snRNA recycling during mRNA splicing Homo sapiens
metabolism isoform TUT4 catalyzes mono- or oligo-uridylylation of precursor let-7 (pre-let-7). Let-7 RNA is broadly expressed in somatic cells and regulates cellular proliferation and differentiation. Mono-uridylylation of pre-let-7 by TUT4 promotes subsequent Dicer processing to up-regulate let-7 biogenesis Homo sapiens
metabolism isoform TUT7 catalyzes mono- or oligo-uridylylation of precursor let-7 (pre-let-7). Let-7 RNA is broadly expressed in somatic cells and regulates cellular proliferation and differentiation. Mono-uridylylation of pre-let-7 by TUT7 promotes subsequent Dicer processing to up-regulate let-7 biogenesis Homo sapiens