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Literature summary for 2.7.7.52 extracted from

  • Sement, F.M.; Ferrier, E.; Zuber, H.; Merret, R.; Alioua, M.; Deragon, J.M.; Bousquet-Antonelli, C.; Lange, H.; Gagliardi, D.
    Uridylation prevents 3 trimming of oligoadenylated mRNAs (2013), Nucleic Acids Res., 41, 7115-7127.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.52

Cloned(Commentary)

Cloned (Comment) Organism
-
 Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
D491A/D493A complete loss of activity Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Arabidopsis thaliana 5829
-

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana O64642
-
-
Arabidopsis thaliana Col-0 O64642
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme shows strong preference for uridine and a distributive activity for the first added nucleotides. URT1 uridylates oligoadenylated mRNAs Arabidopsis thaliana ?
-
 ?
additional information enzyme shows strong preference for uridine and a distributive activity for the first added nucleotides. URT1 uridylates oligoadenylated mRNAs Arabidopsis thaliana Col-0 ?
-
 ?
UTP + RNAn
-
 Arabidopsis thaliana diphosphate + RNAn+1
-
 ?
UTP + RNAn
-
 Arabidopsis thaliana Col-0 diphosphate + RNAn+1
-
 ?

Synonyms

Synonyms Comment Organism
At2g45620
-
 Arabidopsis thaliana
URT1
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
physiological function oligo(A)-tailed mRNAs are uridylated by the cytosolic UTP:RNA uridylyltransferase URT1, and URT1 has no major impact on mRNA degradation rates. In absence of uridylation, oligo(A) tails are trimmed, indicating that uridylation protects oligoadenylated mRNAs from 3'-ribonucleolytic attacks. URT1 mutants display an increase in 3'-truncated transcripts Arabidopsis thaliana