Literature summary for 2.7.7.52 extracted from

Talsky, K.B.; Collins, K.
Strand-asymmetric endogenous Tetrahymena small RNA production requires a previously uncharacterized uridylyltransferase protein partner (2012), RNA, 18, 1553-1562.

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Organism

Organism	UniProt	Comment	Textmining
Tetrahymena thermophila	I1Y9V9	isoform Rsp1	-

Subunits

Subunits	Comment	Organism
More	isoform Rsp1 associates with uridylyltransferase Rdn1-RNA-dependent RNA polymerase Rdf1 or Rdn1-Rdf2 subcomplexes, creating Rsp1 complexes RSPCs that are physically separate from RNA-dependent RNA polymerase complexes RDRCs. The uridylyltransferase activity of Rdn1 is greatly reduced in RSPCs compared with RDRCs, suggesting enzyme regulation by the alternative partners	Tetrahymena thermophila

Synonyms

Synonyms	Comment	Organism
RNA silencing protein 1	-	Tetrahymena thermophila
Rsp1	-	Tetrahymena thermophila

General Information

General Information	Comment	Organism
physiological function	isoform Rsp1 associates with uridylyltransferase Rdn1-RNA-dependent RNA polymerase Rdf1 or Rdn1-Rdf2 subcomplexes, creating Rsp1 complexes RSPCs that are physically separate from RNA-dependent RNA polymerase complexes RDRCs. The uridylyltransferase activity of Rdn1 is greatly reduced in RSPCs compared with RDRCs, suggesting enzyme regulation by the alternative partners. Despite the loss of all known RDRC-generated classes of endogenous sRNAs, RSP1 gene knockout is tolerated in growing cells. A minority class of dicer protein Dcr2-dependent sRNAs persists in cells lacking Rsp1 with increased size heterogeneity	Tetrahymena thermophila

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Release 2023.1 (January 2023)