Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.7.52 extracted from

  • Aphasizhev, R.; Aphasizheva, I.; Simpson, L.
    A tale of two TUTases (2003), Proc. Natl. Acad. Sci. USA, 100, 10617-10622.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression of RET2 in Leishmania tarentolae cells as cytosolic enzyme by removing the mitochondrial targeting signal sequence Trypanosoma brucei

Inhibitors

Inhibitors Comment Organism Structure
additional information RNA interference, i.e. RNAi, induced by tetracyclines causes down-regulation of RET1 and RET2 expression in vitro and in vivo Trypanosoma brucei

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Trypanosoma brucei down-regulation of RET1, but not of RET2, affects length distribution of gRNA 3' oligo(U) tails ?
-
?
UTP + RNAn Trypanosoma brucei addition of non-coded poly(U) tail to gRNAs diphosphate + RNAn+1
-
?

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
-
RET1 and RET2, i.e. RNA editing TUTases 1 and 2, as components of different editing complexes
-

Purification (Commentary)

Purification (Comment) Organism
recombinant TAP-tagged enzyme from Leishmania tarentolae cells Trypanosoma brucei

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information down-regulation of RET1, but not of RET2, affects length distribution of gRNA 3' oligo(U) tails Trypanosoma brucei ?
-
?
UTP + RNAn the mitochondrial enzyme adds a single U to the 3'-end of single-stranded RNA Trypanosoma brucei diphosphate + RNAn+1
-
?
UTP + RNAn addition of non-coded poly(U) tail to gRNAs Trypanosoma brucei diphosphate + RNAn+1
-
?

Synonyms

Synonyms Comment Organism
3' terminal uridylyl transferase
-
Trypanosoma brucei
RET i.e. RNA editing TUTase Trypanosoma brucei