Cloned (Comment) | Organism |
---|---|
expression of RET2 in Leishmania tarentolae cells as cytosolic enzyme by removing the mitochondrial targeting signal sequence | Trypanosoma brucei |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | RNA interference, i.e. RNAi, induced by tetracyclines causes down-regulation of RET1 and RET2 expression in vitro and in vivo | Trypanosoma brucei |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Trypanosoma brucei | down-regulation of RET1, but not of RET2, affects length distribution of gRNA 3' oligo(U) tails | ? | - |
? | |
UTP + RNAn | Trypanosoma brucei | addition of non-coded poly(U) tail to gRNAs | diphosphate + RNAn+1 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma brucei | - |
RET1 and RET2, i.e. RNA editing TUTases 1 and 2, as components of different editing complexes | - |
Purification (Comment) | Organism |
---|---|
recombinant TAP-tagged enzyme from Leishmania tarentolae cells | Trypanosoma brucei |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | down-regulation of RET1, but not of RET2, affects length distribution of gRNA 3' oligo(U) tails | Trypanosoma brucei | ? | - |
? | |
UTP + RNAn | the mitochondrial enzyme adds a single U to the 3'-end of single-stranded RNA | Trypanosoma brucei | diphosphate + RNAn+1 | - |
? | |
UTP + RNAn | addition of non-coded poly(U) tail to gRNAs | Trypanosoma brucei | diphosphate + RNAn+1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3' terminal uridylyl transferase | - |
Trypanosoma brucei |
RET | i.e. RNA editing TUTase | Trypanosoma brucei |