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Literature summary for 2.7.7.50 extracted from
- Hydrogen peroxide yields mechanistic insights into human mRNA capping enzyme function (2017), PLoS ONE, 12, e0186423 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli DE3 cells | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| hydrogen peroxide | inactivates the enzyme directly through irreversible oxidation of Cys126 | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + (5')pp-mRNA | Homo sapiens | - |
diphosphate + G(5')ppp-mRNA | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Ni-NTA column chromatography and Mono S column chromatography | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + (5')pp-mRNA | - |
Homo sapiens | diphosphate + G(5')ppp-mRNA | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * about 40000, guanalyltransferase domain of the mRNA capping enzyme, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GTase | - |
Homo sapiens |
| guanylyltransferase | - |
Homo sapiens |
| HCE | - |
Homo sapiens |
| mRNA capping enzyme | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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